An increased prevalence of medical co-morbidities may underscore future growth in the numbers of men requiring penile prostheses

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Despite effective oral therapies for erectile dysfunction (ED), a proportion of patients will require additional treatments. For patients who are refractory to non-surgical interventions, insertion of a penile prosthesis remains the gold standard (1). In their review of ‘A history of penile implants’, Rodriguez and Pastuszak (2) explored the evolution of penile prosthesis design and surgical techniques. Another progression when considering the history of penile prosthetics is the shifting patient demographics of those men requiring penile implantation. Indeed, the worsening health status and increased prevalence of medical co-morbidities that are directly related to the development of ED has the potential to radically increase the amount of men needing penile implants in the future. Rates of ED and the number of men seeking treatment are expected to continue to grow in the United States over the next few decades (3). Along with an aging population, the prevalence of medical co-morbidities also on the rise. Indeed, many of conditions that are becoming more commonplace in society have been directly implicated in the pathogenesis of ED. Moreover, some of these conditions are also associated with a poor response to firstline therapies like PDE5 inhibitors. This lack of response is known to accelerate the progression of ED and leads to increased utilization of more advanced interventions such as placement of penile prostheses (4-6). Diabetic men, for example, are 1.6–2.1 times more likely to advance to more invasive treatments within 5 years of ED diagnosis, or from the initiation of oral therapy (4). Indeed, men receiving penile implants from 2001 to 2010 were increasingly sicker with more co-morbidities and lower 10-year predicted survival rates (7). As the number of co-morbid conditions increase, the odds of a patient going on to receive a penile implant should also increase (5). If one examines the patients receiving a penile prosthesis in the United States; hypertension, dyslipidemia, and diabetes mellitus were the amongst the most common co-morbidities (6). Therefore, the number of patients requiring penile prostheses should mirror the increases in these medical co-morbidities. Early and proper identification of these men should allow practitioners to avoid prolonged trials of less invasive, but more expensive treatments since they are very likely to be ineffective. Identification of these patients early on may help with the development of an under-utilized, but highly effective intervention for ED—the penile prosthesis.